Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes
نویسندگان
چکیده
Skin cancer is the most widespread worldwide, mainly caused by exposure to ultraviolet radiation (UV) in sunlight. Utilizing topical preventive agents routinely daily used cosmetics may prevent UV-related skin damages and cancers. ?-Oryzanol (GO) a natural component derived from rice bran oil, with potential antioxidant anti-aging properties. We biologically thorough studied anticancer effects of GO vitro found effective signaling pathways, then evaluated sun protection factor prepared formulation, finally investigated long-term GO-loaded nanoethosomes (GO-NEs) against UVB-induced mice. GO-NEs could effectively cancer. Our results suggest that be utilized as an innovative ingredient cosmetics.
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ژورنال
عنوان ژورنال: Life Sciences
سال: 2021
ISSN: ['1879-0631', '0300-9653', '0024-3205']
DOI: https://doi.org/10.1016/j.lfs.2021.119759